Varied doses and chemical forms of selenium supplementation differentially affect mouse intestinal physiology.
Identifieur interne : 000299 ( Main/Exploration ); précédent : 000298; suivant : 000300Varied doses and chemical forms of selenium supplementation differentially affect mouse intestinal physiology.
Auteurs : Qixiao Zhai [République populaire de Chine] ; Yue Xiao [République populaire de Chine] ; Peng Li [République populaire de Chine] ; Fengwei Tian [République populaire de Chine] ; Jianxin Zhao [République populaire de Chine] ; Hao Zhang [République populaire de Chine] ; Wei Chen [République populaire de Chine]Source :
- Food & function [ 2042-650X ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Compléments alimentaires (analyse), Humains (MeSH), Intestins (effets des médicaments et des substances chimiques), Intestins (immunologie), Intestins (microbiologie), Mâle (MeSH), Protéomique (MeSH), Salmonella typhimurium (physiologie), Salmonelloses (immunologie), Salmonelloses (microbiologie), Salmonelloses (traitement médicamenteux), Souris (MeSH), Souris de lignée C57BL (MeSH), Sélénite de sodium (administration et posologie), Sélénométhionine (administration et posologie).
- MESH :
- administration et posologie : Sélénite de sodium, Sélénométhionine.
- analyse : Compléments alimentaires.
- effets des médicaments et des substances chimiques : Intestins.
- immunologie : Intestins, Salmonelloses.
- microbiologie : Intestins, Salmonelloses.
- physiologie : Salmonella typhimurium.
- traitement médicamenteux : Salmonelloses.
- Animaux, Humains, Mâle, Protéomique, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals (MeSH), Dietary Supplements (analysis), Humans (MeSH), Intestines (drug effects), Intestines (immunology), Intestines (microbiology), Male (MeSH), Mice (MeSH), Mice, Inbred C57BL (MeSH), Proteomics (MeSH), Salmonella Infections (drug therapy), Salmonella Infections (immunology), Salmonella Infections (microbiology), Salmonella typhimurium (physiology), Selenomethionine (administration & dosage), Sodium Selenite (administration & dosage).
- MESH :
- chemical , administration & dosage : Selenomethionine, Sodium Selenite.
- analysis : Dietary Supplements.
- drug effects : Intestines.
- drug therapy : Salmonella Infections.
- immunology : Intestines, Salmonella Infections.
- microbiology : Intestines, Salmonella Infections.
- physiology : Salmonella typhimurium.
- Animals, Humans, Male, Mice, Mice, Inbred C57BL, Proteomics.
Abstract
In this study, the effects of three doses (diets containing <0.01, 0.15, 0.40 mg kg-1 Se) and two forms (sodium selenite and selenomethionine) of dietary Se supplementation on the intestinal physiology of untreated, dextran sodium sulfate-treated, and Salmonella typhimurium-infected mice were evaluated. The underlying modes of action of the varied doses and forms of Se supplementation were analyzed using fecal metabolomic and jejunal proteomic approaches. Compared with adequate Se (0.15 mg kg-1 Se) supplementation, Se-deficiency supplementation adversely affected the gut barrier and intestinal immune responses of the untreated mice and increased their susceptibility to experimental colitis and pathogen infection. In contrast, supranutritional Se (0.40 mg kg-1 Se) supplementation improved mouse intestinal physiology compared with adequate Se supplementation. Varied doses of Se supplementation differentially perturbed the fecal metabolic profiles of and jejunal protein expression in mice. Further, both forms of dietary Se supplementation, i.e., sodium selenite and selenomethionine, showed similar effects on the gut barrier and intestinal immune homeostasis but differentially affected fecal metabolites, such as neurosubstances and immunomodulators, and induced significant proteomic variations in various pathways, including the xenobiotic detoxification pathway and glutathione metabolism. Our results indicate that the doses and chemical forms of Se should be considered when developing dietary nutritional supplements for gut health.
DOI: 10.1039/c9fo00278b
PubMed: 31397465
Affiliations:
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R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. 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China and National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122</wicri:regionArea><wicri:noRegion>Jiangsu 214122</wicri:noRegion></affiliation></author><author><name sortKey="Tian, Fengwei" sort="Tian, Fengwei" uniqKey="Tian F" first="Fengwei" last="Tian">Fengwei Tian</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122</wicri:regionArea><wicri:noRegion>Jiangsu 214122</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Jianxin" sort="Zhao, Jianxin" uniqKey="Zhao J" first="Jianxin" last="Zhao">Jianxin Zhao</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. 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China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and Beijing Innovation Center of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Food & function</title><idno type="eISSN">2042-650X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Dietary Supplements (analysis)</term><term>Humans (MeSH)</term><term>Intestines (drug effects)</term><term>Intestines (immunology)</term><term>Intestines (microbiology)</term><term>Male (MeSH)</term><term>Mice (MeSH)</term><term>Mice, Inbred C57BL (MeSH)</term><term>Proteomics (MeSH)</term><term>Salmonella Infections (drug therapy)</term><term>Salmonella Infections (immunology)</term><term>Salmonella Infections (microbiology)</term><term>Salmonella typhimurium (physiology)</term><term>Selenomethionine (administration & dosage)</term><term>Sodium Selenite (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Compléments alimentaires (analyse)</term><term>Humains (MeSH)</term><term>Intestins (effets des médicaments et des substances chimiques)</term><term>Intestins (immunologie)</term><term>Intestins (microbiologie)</term><term>Mâle (MeSH)</term><term>Protéomique (MeSH)</term><term>Salmonella typhimurium (physiologie)</term><term>Salmonelloses (immunologie)</term><term>Salmonelloses (microbiologie)</term><term>Salmonelloses (traitement médicamenteux)</term><term>Souris (MeSH)</term><term>Souris de lignée C57BL (MeSH)</term><term>Sélénite de sodium (administration et posologie)</term><term>Sélénométhionine (administration et posologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Selenomethionine</term><term>Sodium Selenite</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Sélénite de sodium</term><term>Sélénométhionine</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Compléments alimentaires</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Dietary Supplements</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Intestines</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Salmonella Infections</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Intestins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Intestins</term><term>Salmonelloses</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Intestines</term><term>Salmonella Infections</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Intestins</term><term>Salmonelloses</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Intestines</term><term>Salmonella Infections</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Salmonelloses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Proteomics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Mâle</term><term>Protéomique</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, the effects of three doses (diets containing <0.01, 0.15, 0.40 mg kg<sup>-1</sup> Se) and two forms (sodium selenite and selenomethionine) of dietary Se supplementation on the intestinal physiology of untreated, dextran sodium sulfate-treated, and Salmonella typhimurium-infected mice were evaluated. The underlying modes of action of the varied doses and forms of Se supplementation were analyzed using fecal metabolomic and jejunal proteomic approaches. Compared with adequate Se (0.15 mg kg<sup>-1</sup> Se) supplementation, Se-deficiency supplementation adversely affected the gut barrier and intestinal immune responses of the untreated mice and increased their susceptibility to experimental colitis and pathogen infection. In contrast, supranutritional Se (0.40 mg kg<sup>-1</sup> Se) supplementation improved mouse intestinal physiology compared with adequate Se supplementation. Varied doses of Se supplementation differentially perturbed the fecal metabolic profiles of and jejunal protein expression in mice. Further, both forms of dietary Se supplementation, i.e., sodium selenite and selenomethionine, showed similar effects on the gut barrier and intestinal immune homeostasis but differentially affected fecal metabolites, such as neurosubstances and immunomodulators, and induced significant proteomic variations in various pathways, including the xenobiotic detoxification pathway and glutathione metabolism. Our results indicate that the doses and chemical forms of Se should be considered when developing dietary nutritional supplements for gut health.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31397465</PMID><DateCompleted><Year>2020</Year><Month>02</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2042-650X</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>9</Issue><PubDate><Year>2019</Year><Month>Sep</Month><Day>01</Day></PubDate></JournalIssue><Title>Food & function</Title><ISOAbbreviation>Food Funct</ISOAbbreviation></Journal><ArticleTitle>Varied doses and chemical forms of selenium supplementation differentially affect mouse intestinal physiology.</ArticleTitle><Pagination><MedlinePgn>5398-5412</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1039/c9fo00278b</ELocationID><Abstract><AbstractText>In this study, the effects of three doses (diets containing <0.01, 0.15, 0.40 mg kg<sup>-1</sup> Se) and two forms (sodium selenite and selenomethionine) of dietary Se supplementation on the intestinal physiology of untreated, dextran sodium sulfate-treated, and Salmonella typhimurium-infected mice were evaluated. The underlying modes of action of the varied doses and forms of Se supplementation were analyzed using fecal metabolomic and jejunal proteomic approaches. Compared with adequate Se (0.15 mg kg<sup>-1</sup> Se) supplementation, Se-deficiency supplementation adversely affected the gut barrier and intestinal immune responses of the untreated mice and increased their susceptibility to experimental colitis and pathogen infection. In contrast, supranutritional Se (0.40 mg kg<sup>-1</sup> Se) supplementation improved mouse intestinal physiology compared with adequate Se supplementation. Varied doses of Se supplementation differentially perturbed the fecal metabolic profiles of and jejunal protein expression in mice. Further, both forms of dietary Se supplementation, i.e., sodium selenite and selenomethionine, showed similar effects on the gut barrier and intestinal immune homeostasis but differentially affected fecal metabolites, such as neurosubstances and immunomodulators, and induced significant proteomic variations in various pathways, including the xenobiotic detoxification pathway and glutathione metabolism. Our results indicate that the doses and chemical forms of Se should be considered when developing dietary nutritional supplements for gut health.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhai</LastName><ForeName>Qixiao</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Yue</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Peng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tian</LastName><ForeName>Fengwei</ForeName><Initials>F</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-8511-4546</Identifier><AffiliationInfo><Affiliation>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jianxin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Hao</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Wei</ForeName><Initials>W</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3348-4710</Identifier><AffiliationInfo><Affiliation>State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China. chenwei66@jiangnan.edu.cn and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China and Beijing Innovation Center of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, P. R. China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>08</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Food Funct</MedlineTA><NlmUniqueID>101549033</NlmUniqueID><ISSNLinking>2042-6496</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>964MRK2PEL</RegistryNumber><NameOfSubstance UI="D012645">Selenomethionine</NameOfSubstance></Chemical><Chemical><RegistryNumber>HIW548RQ3W</RegistryNumber><NameOfSubstance UI="D018038">Sodium Selenite</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="N">Dietary Supplements</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007422" MajorTopicYN="N">Intestines</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040901" MajorTopicYN="N">Proteomics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012480" MajorTopicYN="N">Salmonella Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012486" MajorTopicYN="N">Salmonella typhimurium</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012645" MajorTopicYN="N">Selenomethionine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018038" MajorTopicYN="N">Sodium Selenite</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31397465</ArticleId><ArticleId IdType="doi">10.1039/c9fo00278b</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhai, Qixiao" sort="Zhai, Qixiao" uniqKey="Zhai Q" first="Qixiao" last="Zhai">Qixiao Zhai</name></noRegion><name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name><name sortKey="Li, Peng" sort="Li, Peng" uniqKey="Li P" first="Peng" last="Li">Peng Li</name><name sortKey="Tian, Fengwei" sort="Tian, Fengwei" uniqKey="Tian F" first="Fengwei" last="Tian">Fengwei Tian</name><name sortKey="Xiao, Yue" sort="Xiao, Yue" uniqKey="Xiao Y" first="Yue" last="Xiao">Yue Xiao</name><name sortKey="Zhang, Hao" sort="Zhang, Hao" uniqKey="Zhang H" first="Hao" last="Zhang">Hao Zhang</name><name sortKey="Zhao, Jianxin" sort="Zhao, Jianxin" uniqKey="Zhao J" first="Jianxin" last="Zhao">Jianxin Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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